Nicotinamide mononucleotide (NMN) is a nucleotide derived from ribose and nicotinamide, it is the main precursor of nicotinamide adenine dinucleotide (NAD+)
an essential coenzyme for vital cellular physiological activities such as metabolism, cell death, aging, DNA repair, gene expression, and neuroinflammation
maintenance of normal NAD+ status is important for health
NAD+ cannot be absorbed orally or pass through the cell membrane, elevating NAD+ concentrations can be accomplished by supplementing the diet with its precursor such as
NMN
NMN is a bioactive nucleotide with
the β configuration showing better bioactivity. It has good water solubility, and its solution is acidic
NAD+ declines with age, average NAD+ concentration in human samples is several times lower in adults than in new borns
Reduced NAD+ levels are associated with a wide range of the hallmarks of ageing, from wrinkles to metabolic disorders and
neurodegenerative diseases
results showed that NMN increased aerobic capacity during exercise training improved muscle strength and performance during the 30-
second chair stand test and walking speed, decreased blood pressure, pulse pressure, and blood glucose and increased the telomere length of PBMCs
More than 12 clinical trials conducted, all studies state NMN up to 1250gm per day is safe and no adverse effects were observed
NMN was shown to improve aerobic capacity in humans
NMN intake (250 mg/day) in obese postmenopausal women with
prediabetes for 10 weeks ( a
randomized, placebo-controlled, double-blind trial) reporting significant improvement was found in protein kinase AKT,mTOR protein, and insulin sensitivity
NMN intake in the afternoon was effective in improving drowsiness among several factors of subjective fatigue
TSA Tekk provides the purest and most bioactive form of B-NMN in 500mg and 1000mg dose options, so let us improve the quality of life together
Recommended to consume with breakfast
Resveratrol (3,5,4′-trihydroxy-trans- stilbene) belongs to polyphenols’ stilbenoids group
considered a potential candidate for prevention and treatment of several types of cancer.
resveratrol anticancer properties have been confirmed by many in vitro and in vivo studies, which shows that resveratrol is able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression).
Anti-oxidant and anti-inflammatory – helps reduce oxidative stress markers (García-Martínez BI, Ruiz- Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VM. Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes. Int J Mol Sci. 2023 Apr 18;24(8):7422. doi: 10.3390/ijms24087422. PMID: 37108584; PMCID: PMC10138491)’
NMN combined with resveratrol
could increase the levels of NAD+ in
the heart and muscle by about 1.6
times and 1.7 times vs NMN alone
(Bai LB, Yau LF, Tong TT, Chan WH, Zhang W, Jiang ZH. Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacol Res Perspect. 2022 Aug;10(4):e00986. doi: 10.1002/prp2.986. PMID: 35844164; PMCID: PMC9289528)
May have cognitive benefits(Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24- month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr. 2021 Mar;40(3):820-829. doi: 10.1016/j.clnu.2020.08.025. Epub 2020 Aug 27. PMID: 32900519)
Clinical trials have shown that RV and trans-RV supplementation is safe and
well tolerated at different doses between 0.5-2gm
- Bleeding disorders
- Hormone-sensitive conditions (e.g.,uterine fibroids, breast cancer)
- Pregnant women
- High quality Protein containing all essential amino acids
- Contains vitamins and minerals
- 20+gm protein in 100gm serving
- 0 trans fats
- Easy to digest protein and high absorption
- Protein guidelines state consumption of 0.8-1.5gm of protein per kg of bodyweight
- Protein sources should contain all EAA in the right proportion
- Protein consumption can be distributed during the day to positively affect muscle protein synthesis
- Percentage of protein as essential amino acids (EAA),
- Profile of EAAs
- Total ileal digestibility (TID)
- The highest quality source of protein (e.g. Whey protein) can help optimize each of the above categories resulting in an adequate delivery of EAA to appropriate tissue.
Proteins are vital for the growth and repair of body tissues. This includes the repair of muscle tissue after exercise, as well as the maintenance and growth of skin, hair, and nails
How it can be used
Nutritional Support in Malnutrition :
For patients experiencing malnutrition, Proteins are crucial for tissue repair and muscle building, while vitamins support various biochemical functions and immune health.
Post-Surgery Recovery
After surgery, the body requires additional protein to heal tissues and regain strength.
A high-protein, multivitamin supplement can help meet these increased demands, supporting faster and more effective recovery.
Support for Muscle Health in Elderly
As people age, they can experience sarcopenia, or loss of muscle mass and strength. protein
and multivitamin supplements can help counteract these effects by providing the necessary nutrients
Supports nutritional needs during the hypermetabolic and inflammatory state :
- Helps with reducing muscle atrophy
- Supports metabolic processes
- Promotes tissue repair
- Provides energy
- Can help in maintaining weight
- In order to provide the best surgical support, both carbohydrate and protein intake should be considered.
- Following surgery, intake of essential amino acids to activate protein synthesis, followed by a more prolonged availability of both essential and non-essential amino acids to maximize the net gain in body protein and gluconeogenic precursors
- carbohydrate and protein intake would ensure optimal nourishment prior to surgery (Weimann et al.,2017)
higher levels of taurine metabolites associated with a lower prevalence of type 2 diabetes and lower glucose levels
higher taurine levels were associated with lower levels of the inflammation marker, C-reactive protein (CRP).
Vitamin D deficiency can result in serious health consequences and will be limiting factor in the goal improve quality of life. The only reliable way to complete vitamin
D intake is through food fortified with vitamin D or by taking Vitamin D supplements. The dosage and frequency of supplements will vary on blood levels of vitamin
Vitamin K2 can help reduce bone loss & maintain bone health
Positive effects on blood vessels and heart health -Improves arterial stiffness, less coronary artery calcification
Oral supplementation of low-molecular-weight collagen peptides could improve the wrinkles, elasticity, hydration, and barrier integrity of photoaged facial skin
Collagen supplementation can also help in maintaining joint health.
Omega 3 has cognitive improvement effects in cognitively impaired individuals, mainly in relation to memory. Omega 3 can have brain protective effects and can have anti-inflammatory benefits.
References
Alex A, Abbott KA, McEvoy M, Schofield PW, Garg ML. Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: a systematic review and meta-analysis. Nutr Rev. 2020 Jul 1;78(7):563-578. doi: 10.1093/nutrit/nuz073. PMID: 31841161.
Külzow N, Witte AV, Kerti L, et al. Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults. J Alzheimers Dis. 2016;51(3):713-725. doi:10.3233/JAD-150886
Jackson PA, Forster JS, Bell JG, Dick JR, Younger I, Kennedy DO. DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults. Nutrients. 2016;8(2):86. Published 2016 Feb 9. doi:10.3390/nu8020086
Pase MP, Grima N, Cockerell R, et al. The effects of long-chain omega-3 fish oils and multivitamins on cognitive and cardiovascular function: a randomized, controlled clinical trial. J Am Coll Nutr. 2015;34(1):21-31. doi:10.1080/07315724.2014.880660
Boespflug EL, McNamara RK, Eliassen JC, Schidler MD, Krikorian R. Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults with Subjective Memory Impairment. J Nutr Health Aging. 2016;20(2):161-169. doi:10.1007/s12603-015-0609-6
Stonehouse W, Conlon CA, Podd J, et al. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. Am J Clin Nutr. 2013;97(5):1134-1143. doi:10.3945/ajcn.112.053371
Phillips MA, Childs CE, Calder PC, Rogers PJ. No Effect of Omega-3 Fatty Acid Supplementation on Cognition and Mood in Individuals with Cognitive Impairment and Probable Alzheimer's Disease: A Randomised Controlled Trial. Int J Mol Sci. 2015;16(10):24600-24613. Published 2015 Oct 16. doi:10.3390/ijms161024600
Magnesium is important for healthy bones. People with higher intakes of magnesium have a higher bone mineral density, which is important in reducing the risk of bone fractures and osteoporosis. Older adults have lower dietary intakes of magnesium than younger adults. In addition, magnesium absorption from the gut decreases and renal magnesium excretion increases with age.
Older adults are also more likely to have chronic diseases or take medications that alter magnesium status, which can increase their risk of magnesium depletion